Type 2 Iodothyronine Deiodinase Levels Are Higher in Slow-Twitch than Fast-Twitch Mouse Skeletal Muscle and Are Increased in Hypothyroidism
نویسندگان
چکیده
منابع مشابه
Type 2 iodothyronine deiodinase is upregulated in rat slow- and fast-twitch skeletal muscle during cold exposure.
During cold acclimation, shivering is progressively replaced by nonshivering thermogenesis. Brown adipose tissue (BAT) and skeletal muscle are relevant for nonshivering thermogenesis, which depends largely on thyroid hormone. Since the skeletal muscle fibers progressively adapt to cold exposure through poorly defined mechanisms, our intent was to determine whether skeletal muscle type 2 deiodin...
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The effects of phosphorylation status on Ca2+release and Ca2+ removal were studied in fast-twitch flexor digitorum brevis and slow-twitch soleus skeletal muscle fibers enzymatically isolated from wild-type and phospholamban knockout (PLBko) mice. In all fibers the adenosine 3',5'-cyclic monophosphate-dependent protein kinase (PKA) inhibitor H-89 decreased the peak amplitude of the intracellular...
متن کاملType 2 iodothyronine deiodinase in skeletal muscle: effects of hypothyroidism and fasting.
CONTEXT The iodothyronine deiodinases D1, D2, and D3 enable tissue-specific adaptation of thyroid hormone levels in response to various conditions, such as hypothyroidism or fasting. The possible expression of D2 mRNA in skeletal muscle is intriguing because this enzyme could play a role in systemic as well as local T3 production. OBJECTIVE We determined D2 activity and D2 mRNA expression in ...
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Smaller diaphragmatic motor unit potentials (MUPs) compared to MUPs of limb muscles lead to the hypothesis that diaphragmatic muscle fibers, being the generators of MUPs, might be also smaller. We compared autopsy samples of costal diaphragm and vastus lateralis of healthy men with respect to fibers' size and expression of slow myosin heavy chain isoform (MyHC-1) and fast 2A isoform (MyHC-2A). ...
متن کاملFast and slow twitch units in a human muscle.
A study has been made of the isometric twitches of single motor units in the extensor hallucis brevis (EHB) muscle in man. The twitch contraction times ranged from 35 to 98 msec and the pooled results indicated the presence of at least two types of unit. The recorded twitch tensions also varied considerably (from 2 to 14 g) but were not related to the twitch speeds. The twitch tension developed...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2010
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2010-0631